I've got LMDE on bare metal on two computers. One was just to see how well it ran on an old 32 bit laptop that I really should discard but keep it for testing 32 bit systems and the other is a desktop system. It's not bad and it makes a perfectly adequate desktop system, with great stability. Curiously, I had some issues getting AppImages to run, but I haven't dug into that at this time and only tried a couple.
However, the desktop system will be switched to ElementaryOS. That one gets switched out regularly. LMDE has been on it for a while, so this weekend it'll get swapped over.
Anyhow, it's a very workable desktop OS. It's feature-rich right out of the box, has everything from a firewall to backup system already installed, and has a Debian backup for rock-solid stability.