That's a fine question, but I don't really have a fine answer... I'm currently run 4 different distros on 3 different machines. My wife's notebook is running LinuxLite 4.8, my project computer has Peppermint 10, & MX Linux 19 something on it (currently default drive booting to Peppermint 10), The last computer is running Manjaro Cinnamon. So, I think I have to give the nod to Manjaro at the moment.
I had dabbled with Peppermint several years ago, leaned a bit toward Mint 13 back then), but never really got mainstream with them back then. Since Gates has decided to kill us and track us all with vaccines, I have decided to move completely to Linux. Peppermint is set up OOB to allow you to run MS apps in the browser if needed. That's why I was interested in it again. Downside is that Mark Greaves has passed away and that worries me a bit.
Back on point to your question, Manjaro Cinnamon has a bit more comfortable feel to it after coming off of 30 years of Windows; I guess that's why I am more at home with it. I have used several different DE and can manage quite well with any of them but I'm really pretty happy with Manjaro Cinnamon. Might give MATE a try next. It's really just a hobby now.
I sit here typing this reply on my 9 year old Toshiba Notebook/laptop an I'm looking to reformat one of the SSDs with some flavor or another of Linux for it and then I will be pretty much completely converted. It has a 500 gb ssd in it now: might just set it up to dual boot, IDK.