But I would NOT recommend running WINE with escalated privileges. You shouldn't need to. If you need to access hardware that only came with a Windows app (like my programmable button mouse), just create a Windows VM and use hardware passthrough for whatever component. An example for USB: https://unix.stackexchange.com/questions/250938/qemu-usb-passthrough-windows-guest.
It would help if you told us why you need to run as admin to use WINE.